Formulation: A solid
Formal Name: 4-(4-(4-chlorophenyl-2,3,5,6-d4)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C21H19ClD4FNO2
Formula Weight: 379,9
Shelf life (days): 1460
CAS Number: 1189986-59-1
Notes: Haloperidol-d4 is intended for use as an internal standard for the quantification of haloperidol (Item No. 12014) by GC- or LC-MS. Haloperidol is a typical antipsychotic and dopamine D2-like receptor antagonist (Kis = 0.6, 0.2, and 22 nM, for D2, D3, and D4 receptors, respectively).{25512} It also acts as an inverse agonist at dopamine D2 and D3 receptors (IC50s = 0.8 and 0.6 nM, respectively). Haloperidol also binds to α1- and α2- adrenergic and histamine H1 receptors, as well as the serotonin (5-HT) receptor subtypes 5-HT1D and 5-HT2A (Kds = 17, 600, 260, 40, and 61 nM, respectively).{25511} It inhibits stereotypic behavior induced by apomorphine (Item No. 16094) and amphetamine in rats (ID50s = 0.532 and 0.101 μmol/kg, respectively).{46010} Haloperidol also inhibits apomorphine-induced decreases in prepulse inhibition of the acoustic startle response in rats in a dose-dependent manner.{46011} Formulations containing haloperidol have been used in the treatment of schizophrenia and Tourette syndrome.
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