Formulation: A solid
Formal Name: L-threonylglycyl-L-lysyl-L-alanyl-L-seryl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C54H84N14O14S • XCF3COOH
Formula Weight: 1185,4
Shelf life (days): 1460
Notes: Hemokinin 1 is a tachykinin peptide neurokinin-1 (NK1) receptor agonist.{61979,61980,61981,61982,61983} It induces migration of A375 and B16/F10 melanoma cells when used at a concentration of 1 µM, an effect that can be reversed by the NK1 receptor antagonist L-732,138 (Item No. 30894).{61979} Hemokinin 1 (0.001-0.1 µM) promotes the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs).{61980} It induces the production of prostaglandin E2 (PGE2; Item No. 14010) in human colon mucosal and muscle explants.{61981} Intracerebroventricular administration of hemokinin 1 increases the latency to withdrawal in the tail-flick test in mice in a dose-dependent manner.{61982} It decreases mean arterial pressure (MAP) and heart rate in anesthetized rats when administered at doses ranging from 1 to 30 nmol/kg.{61983}
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