Formulation: A crystalline solid
Formal Name: 2,2'-methylenebis[3,4,6-trichloro-phenol
Purity: ≥98%
Formula Markup: C13H6Cl6O2
Formula Weight: 406,9
Shelf life (days): 1460
CAS Number: 70-30-4
Notes: Hexachlorophene is an organochlorine antiseptic and antibacterial biocide.{41505,41506,41507,41508} It is active against S. aureus (MIC = 1.56 μg/ml), E. faecium isolates from fresh produce (MICs = 5-50 mg/L), Salmonella isolates from meats (MICs = 2.5-25 mg/L), and Pseudomonas isolates from slaughterhouse surfaces (MICs = ≤0.0025-≤0.25 mg/L). Hexachlorophene inhibits severe acute coronavirus 2 (SARS-CoV-2) endoribonuclease (nsp15) in a FRET assay (IC50 = 1.6 µM) and inhibits SARS-CoV-2 replication in infected Vero CCL-81 cells (IC50 = 0.91 µM).{66527} Hexachlorophene inhibits infection of mouse astrocytoma delayed brain tumor (DBT) cells by mouse hepatitis virus (MHV; IC50 = 1.2 μM).{41509} Hexachlorophene also inhibits recombinant human glutathione transferases P1-1 and A3-3 (IC50s = 9.7 and v7 channels expressed in CHO cells (EC50 = 4.61 μM).{41510,41511} In vivo, hexachlorophene is toxic to fasted and non-fasted rats with LD50 values of 215 and 165 mg/kg, respectively.{41512} It reduces R. solani-induced fruit rot in cucumber plants when applied at a concentration of 4.4 kg/ha.{69461}
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