Formulation: A solid
Formal Name: cyclic (1→9)-disulfide, N-acetyl-L-cysteinyl-L-norleucyl-L-arginyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-tryptophylglycyl-L-cysteinamide, trifluoroacetate salt
Purity: ≥98%
Formula Markup: C58H79N19O10S2 • XCF3COOH
Formula Weight: 1266,5
Shelf life (days): 1460
Notes: HS-024 is a cyclic peptide antagonist of melanocortin receptor 4 (MC4R; Ki = 0.29 nM).{69912} It is selective for MC4R over MC1R, MC3R, and MC5R (Kis = 18.6, 5.45, and 3.29 nM, respectively). HS-024 (100 nM) inhibits cAMP accumulation induced by α-melanocyte-stimulating hormone (α-MSH; Item No. 29923) in COS-1 cells expressing human MC1R, MC3R, MC4R, or MC5R. It increases food intake in rats when administered at doses of 0.3, 1, or 3 nmol/animal. Intrathecal administration of HS-024 (1.5 nmol/animal) inhibits mechanical allodynia at 30 minutes post-injection in a rat model of spinal nerve ligation-induced neuropathic pain.{69913} It reduces stress-induced reinstatement of nicotine seeking in the foot shock test in rats.{69914}
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