Formulation: A solid
Formal Name: 6-[[2-(1H-imidazol-5-yl)ethyl]amino]-N-[4-(trifluoromethyl)phenyl]-heptanamide, 2Z-butenedioate
Purity: ≥98%
Formula Markup: C19H25F3N4O • 2C4H4O4
Formula Weight: 614,6
Shelf life (days): 1460
CAS Number: 195867-54-0
Notes: HTMT is a histamine H1 receptor agonist.{47692} It also binds to the histamine H4 receptor (Ki = 1.2 µM) but does not increase calcium mobilization in HEK293 cells expressing the receptor at 10 µM.{47693} HTMT increases intracellular calcium and inositol phosphate levels (EC50s = 19 and 30 µM, respectively) in human peripheral blood lymphocytes.{47694} It increases proliferation of immortalized mouse small, but not large, cholangiocytes, when used at a concentration of 10 µM.{47696} HTMT (10 µg/kg twice per day) increases levels of sheep red blood cell-induced IgG and IgM antibodies in rabbit serum.{47697} It induces scratching in mice when administered at an intradermal dose of 0.2 µmol, an effect that is reduced by the H1 receptor antagonist terfenadine (Item No. 20305).{47695}
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