Formulation: A solid
Formal Name: 2,3,4,4aR,5R,6-hexahydro-12-methyl-1H-5,10bR-propeno-1,7-phenanthrolin-8(7H)-one
Purity: ≥95%
Formula Markup: C16H20N2O
Formula Weight: 256,3
Shelf life (days): 1460
CAS Number: 103548-82-9
Notes: Huperzine B is an alkaloid originally isolated from H. serrata with neuroprotective activity.{65371} It selectively binds to acetylcholinesterase (AChE) over butyrylcholinesterase (BChE; IC50s = 8.2 and 157 µM, respectively).{65369} It is also an antagonist at the NMDA receptor (IC50 = 316.6 µM).{65370} Huperzine B (0.1-100 µM) increases the viability of PC12 cells in a model of hydrogen peroxide-induced cell injury.{65371} It increases glutathione peroxidase (GPX) and catalase (CAT) activities, and decreases malondialdehyde (MDA) levels, in PC12 cells in a model of hydrogen peroxide-induced cell injury when used at concentrations ranging from 10 to 100 µM.
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