Hydroxy Bosentan, CAS 253688-60-7

Formulation: A crystalline solid

Formal Name: 4-(2-hydroxy-1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-benzenesulfonamide

Purity: ≥98%

Formula Markup: C27H29N5O7S

Formula Weight: 567,6

Shelf life (days): 1460

CAS Number: 253688-60-7

Notes: Hydroxy bosentan is an active phase I metabolite of bosentan (Item No. 11731) produced by the cytochrome P450 isoforms CYP3A4 and CYP2C9.{39033,39032} Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM).{22374,22376} Up to 20% of the activity of bosentan may be due to the action of hydroxy bosentan because even though it has a lower affinity for endothelin receptors, its concentration is 3-fold higher in plasma.{39034}

• SKU: CAY22366-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22366-500
• Green Labware: No
• Package Unit: 500 µg
• Quantity Unit: STK