Formulation: A solid
Formal Name: (1R,3R,5S)-8-(methyl-d3)-8-azabicyclo[3.2.1]octan-3-yl (S)-3-hydroxy-2-phenylpropanoate
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C17H20D3NO3
Formula Weight: 292,4
Shelf life (days): 1460
Notes: (–)-Hyoscyamine-d3 is intended for use as an internal standard for the quantification of (–)-hyoscyamine (Item No. 25644) by GC- or LC-MS. (–)-Hyoscyamine is a tropane alkaloid, a muscarinic receptor antagonist, and an isomer of atropine (Item No. 12008).{43484,43485} (–)-Hyoscyamine inhibits the arterial depressor response induced by the muscarinic agonist methacholine in dogs.{43484} It is more effective than atropine at inhibiting EEG arousal in dogs following sciatic nerve stimulation when administered at doses of 0.5 and 1 mg/kg. (–)-Hyoscyamine induces convulsions in and is toxic to mice (LD50 = 95 mg/kg).{43485}
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