Formulation: A solid
Formal Name: methyl 6-amino-6-deoxy-2,3-di-O-tetradecyl-α-D-glucopyranoside
Purity: ≥95%
Formula Markup: C35H71NO5
Formula Weight: 585,9
Shelf life (days): 1460
CAS Number: 1115270-63-7
Notes: IAXO-102 is a glycolipid and an antagonist of toll-like receptor 4 (TLR4).{17575} It inhibits lipid A-induced TLR4 activation in a cell-based assay (IC50 = 5.013 µM). IAXO-102 (10 mg/kg) reduces LPS-induced lethality in mice. It decreases angiotensin II-induced aortic expansion and rupture, as well as the incidence of abdominal aortic aneurysms, in ApoE-/- mice when administered at a dose of 3 mg/kg.{61728}