Formulation: A solid
Formal Name: N-(3-hydroxyphenyl)-adenosine 2′,3′,5′-triacetate
Purity: ≥95%
Formula Markup: C22H23N5O8
Formula Weight: 485,5
Shelf life (days): 1460
CAS Number: 1221412-23-2
Notes: IMM-H007 is an activator of AMP-activated protein kinase (AMPK) and an antagonist of TGF-β1.{67585,67586} It increases AMPK activity in HepG2 cell lysates when used at concentrations ranging from 1 to 100 µM.{67585} IMM-H007 binds to TGF-β1 (Kd = 0.2098 µM) and inhibits the binding of TGF-β1 to TGF-β receptor type 2 (TGFBR2) when used at a concentration of 6 µM.{67586} It increases cholesterol efflux in THP-1 macrophages incubated with isolated mouse ApoB-depleted serum ex vivo when administered at a dose of 100 or 200 mg/kg.{67587} In vivo, IMM-H007 (18 mg/kg) decreases serum levels of triglycerides, total cholesterol, and LDL cholesterol, as well as hepatic lipid accumulation, in a hamster model of high-fat diet-induced hyperlipidemia.{67585} IMM-H007 (200 mg/kg) decreases fibrotic area in wild-type and AMPKα2 knockout mice in a model of cardiac fibrosis induced by the β-adrenergic receptor (β-AR) agonist isoprenaline (isoproterenol; Item No. 15592).{67586} It decreases atherosclerotic lesion area in ApoE-/- mice fed a Paigen diet.{67587}
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