Formulation: A crystalline solid
Formal Name: 4-(1H-imidazol-5-ylmethyl)-piperidine, dihydrobromide
Purity: ≥95%
Formula Markup: C9H15N3 • 2HBr
Formula Weight: 327,1
Shelf life (days): 1460
CAS Number: 164391-47-3
Notes: Immepip is a histamine H3 receptor agonist (KI = 0.4 nM in SK-N-MC cell membranes expressing the human receptor).{52174} It is selective for histamine H3 over H1 and H2 receptors in CHO cell membranes expressing the guinea pig and human receptors, respectively (Kis = >16 μM for both) but also agonizes H4 receptors (KI = 9 nM in SK-N-MC cell membranes expressing the human receptor).{52204,52174} Immepip (5 mg/kg, s.c.) decreases hypothalamic histamine release in anesthetized rats.{52205} It decreases flinching in the formalin test in rats when administered at doses of 5 and 30 mg/kg and inhibits formalin-induced paw edema at 30 mg/kg.{52206}
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