Formulation: A neat oil
Formal Name: (1R,2S,5E,9E,12S)-1,5,9-trimethyl-12-(1-methylethyl)-2-acetate, 15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-ol
Purity: ≥98%
Formula Markup: C22H36O3
Formula Weight: 348,5
Shelf life (days): 1460
CAS Number: 34701-53-6
Notes: Incensole acetate is a diterpene originally isolated from frankincense produced by B. carterii that has diverse biological activities.{39665,61643,61644} It is an activator of transient receptor potential vanilloid 3 (TRPV3) that induces calcium influx in HEK293 cells expressing TRPV3 (EC50 = 16 µM).{61643} Incensole acetate (60-140 µM) inhibits degradation of inhibitor of NF-κB (IκBα) in TNF-α-stimulated HeLa cells.{39665} It reduces apoptosis, increases in malondialdehyde (MDA) levels, and the production of reactive oxygen species (ROS) induced by amyloid-β (25-35) peptide (Item No. 24155) in human olfactory bulb neural stem cells (hOBNSCs).{61644} Incensole acetate (50 mg/kg) reduces paw edema in mice in a model of hind paw inflammation induced by carrageenan.{39665} It also increases the time spent in the open arms of the elevated plus maze and reduces immobility in the forced swim test, indicating anxiolytic and antidepressant-like activity, respectively.{61643}
English
Deutsch
