Formulation: A crystalline solid
Formal Name: α-oxo-1H-indole-3-propanoic acid
Purity: ≥98%
Formula Markup: C11H9NO3
Formula Weight: 203,2
Shelf life (days): 1460
CAS Number: 392-12-1
Notes: Indole-3-pyruvic acid is an endogenous metabolite of tryptophan and intermediate in the biosynthesis of the major auxin hormone, indole-3-acetic acid (IAA; Item No. 16954), in plants.{52871,52872,52873} Indole-3-pyruvic acid (50 and 250 µM) activates the aryl hydrocarbon receptor (AhR) in a reporter assay.{52871} It reduces UVB-induced cytotoxicity and the levels of COX-2 in HaCaT keratinocytes.{52874} Topical administration of indole-3-pyruvic acid (100 µmol) reduces the severity of UVB-induced damage in mouse skin. Dietary administration of indole-3-pyruvic acid (0.1%) reduces diarrhea, colonic inflammation, and the colonic expression of Il1b, Ifng, Tnfa, and Il12b in a mouse model of T cell-mediated colitis.{52871} It increases the time spent in the open arms of the elevated plus maze in mice when administered at a dose of 100 mg/kg.{52872} It also reverses the anxiogenic effect of caffeine (Item No. 14118) and 3-hydroxy kynurenine, but not pentylenetetrazole (Item No. 18682) or phenylethylamine, in the elevated plus maze in mice.
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