Formulation: A solid
Formal Name: [2-(4-iodophenyl)ethyl]-carbamimidothioic acid, 3-(1H-imidazol-4-yl)propyl ester, dihydrobromide
Purity: ≥98%
Formula Markup: C15H19IN4S • 2HBr
Formula Weight: 576,1
Shelf life (days): 1460
CAS Number: 145196-87-8
Notes: Iodophenpropit is a histamine H3 receptor antagonist (pA2 = 9.6 in guinea pig intestine, which has a high endogenous expression of H3 receptors).{60165} It increases forskolin-induced cAMP production in SK-N-MC cells expressing the recombinant human H3 receptor (EC50 = 25.1 nM).{60166} It is also an inhibitor of NR1/NR2A, NR1/NR2B, NR1/NR2C, and NR1/NR2D subunit-containing NMDA receptors (IC50s = 1.3, 1.4, 9.7, and 14 µM, respectively, for the rat recombinant receptors).{60167} Iodophenpropit induces scratching behavior in mice when administered intradermally at a dose of 10 nmol and reduces amygdala-kindled seizure duration in rats (ED50 = 2.54 mg/kg).{60168,16495}
English
Deutsch
