Formulation: A crystalline solid
Formal Name: 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide
Purity: ≥98%
Formula Markup: C22H15Br2N3O4
Formula Weight: 545,2
Shelf life (days): 1460
CAS Number: 1191252-49-9
Notes: IOWH-032 is a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR).{58097,58098} It inhibits CFTR in T84 human colon cells (IC50 = 8.51 µM).{58097} It has rapid inhibitory and slow potentiating effects on human CFTR with apparent Kd values of 6.1 and 0.64 nM, respectively.{58098} IOWH-032 (20 nM) also potentiates currents through CFTR bearing the F508 deletion mutation (ΔF508-CFTR) expressed in X. laevis oocytes. It inhibits, but does not potentiate, mouse CFTR with an apparent Kd value of 42.9 µM.