IOWH-032, CAS 1191252-49-9

Formulation: A crystalline solid

Formal Name: 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide

Purity: ≥98%

Formula Markup: C22H15Br2N3O4

Formula Weight: 545,2

Shelf life (days): 1460

CAS Number: 1191252-49-9

Notes: IOWH-032 is a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR).{58097,58098} It inhibits CFTR in T84 human colon cells (IC50 = 8.51 µM).{58097} It has rapid inhibitory and slow potentiating effects on human CFTR with apparent Kd values of 6.1 and 0.64 nM, respectively.{58098} IOWH-032 (20 nM) also potentiates currents through CFTR bearing the F508 deletion mutation (ΔF508-CFTR) expressed in X. laevis oocytes. It inhibits, but does not potentiate, mouse CFTR with an apparent Kd value of 42.9 µM.

• SKU: CAY30273-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30273-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK