Formulation: A crystalline solid
Formal Name: 2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3(2H)-one, 1,1-dioxide, monohydrochloride
Purity: ≥98%
Formula Markup: C19H23N5O3S • HCl
Formula Weight: 437,9
Shelf life (days): 730
CAS Number: 92589-98-5
Notes: Ipsapirone is a partial agonist of the serotonin (5-HT) receptor 5-HT1A (Ki = 10 nM in hippocampal membranes).{35118} It reduces 5-HT release in rat ventral hippocampus in vivo.{35119} Low doses of ipsapirone decrease, while high doses increase, extracellular dopamine release in murine nucleus accumbens.{35120} Extracellular dopamine levels in murine striatum increase following administration of ipsapirone at concentrations >0.1 mg/kg. Ipsapirone has anxiolytic effects in vivo, inhibiting foot shock-induced aggression and passive avoidance behavior in rats (ED50s = 2.2 and 0.5 mg/kg, respectively).{35121} Formulations containing ipsapirone have been used to treat depression and borderline personality disorder.{35122}
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