IRL 1620 (trifluoroacetate salt)

Formulation: A crystalline solid

Formal Name: N-(3-carboxy-1-oxopropyl)-L-α-aspartyl-L-α-glutamyl-L-α-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-L-tryptophan, trifluoroacetate salt

Purity: ≥98%

Formula Markup: C86H117N17O27 • XCF3COOH

Formula Weight: 1820,9

Shelf life (days): 1460

Notes: IRL 1620 is a peptide endothelin type B (ETB) receptor agonist.{60959} It selectively binds to ETB receptors (Ki = 16 pM) over ETA receptors (IC50 = 1.9 µM) and induces contraction of isolated guinea pig trachea when used at concentrations ranging from 0.01 to 1 µM. IRL 1620 (1 nmol/kg) reduces mean arterial pressure (MAP) in normotensive rats and spontaneously hypertensive rats (SHRs) and diminishes the transient depressor response in SHRs.{60960} It reduces infarct volume and improves motor and neurological function in a rat model of cerebral ischemia.{60961} IRL 1620 also improves spatial memory deficits induced by amyloid-β (Aβ) in a rat model of Alzheimer's disease.

• SKU: CAY30980-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30980-500
• Green Labware: No
• Package Unit: 500 µg
• Quantity Unit: STK