Formulation: A solid
Formal Name: (13aS)-5,8,13,13a-tetrahydro-3,9,10-trimethoxy-6H-dibenzo[a,g]quinolizin-2-ol
Purity: ≥95%
Formula Markup: C20H23NO4
Formula Weight: 341,4
Shelf life (days): 1460
CAS Number: 483-34-1
Notes: (–)-Isocorypalmine is an isoquinoline alkaloid and a metabolite of L-tetrahydropalmitine (L-THP; Item No. 20535) that has been found in Corydalis and has diverse biological activities.{52469,52465,52466,52467,52468} It binds to human dopamine D1-5 receptors with Ki values of 6.2, 41.8, 37.3, 77.4, and 9.5 nM, respectively.{52465} (–)-Isocorypalmine inhibits Epstein-Barr virus-early antigen (EBV-EA) activation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in Raji cells (IC50 = 300 mol ratio/32 pmol TPA), which is predictive for anti-tumor activity.{52466} It is cytotoxic to A549, SKOV3, SK-MEL-2, and HCT15 cancer cells (IC50s = 67.32, 47.37, 47.66, and 67.32 μM, respectively).{52467} (–)-Isocorypalmine is active against clinical strains of C. albicans, C. glabratas, C. krusei, C. parapsilosis, and C. neoformans (MICs = 40-320 μg/ml).{52468}
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