Formulation: A crystalline solid
Formal Name: 3-(3-hydroxy-4-methoxyphenyl)-2-propenoic acid
Purity: ≥98%
Formula Markup: C10H10O4
Formula Weight: 194,2
Shelf life (days): 1460
CAS Number: 537-73-5
Notes: Isoferulic acid is a cinnamic acid derivative that has antidiabetic activity.{40026,40027} It binds to and activates α1-adrenergic receptors (IC50 = 1.4 µM) to enhance secretion of β-endorphin (EC50 = 52.2 nM) and increase glucose use in vitro. Isoferulic acid increases glucose uptake and enhances glycogen synthesis in isolated soleus muscles from streptozocin-induced diabetic rats.{40025} In vivo, isoferulic acid induces a dose-dependent reduction in plasma glucose levels in streptozocin-induced diabetic rats. It also inhibits absorbance of intestinal maltase and sucrose via α-glucosidase in vitro (IC50s = 760 and 450 µM, respectively).{40028}
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