Formulation: A crystalline solid
Formal Name: 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid, monohydrochloride
Purity: ≥95%
Formula Markup: C6H9NO2 • HCl
Formula Weight: 163,6
Shelf life (days): 1460
CAS Number: 68547-97-7
Notes: Isoguvacine is a GABAA receptor agonist.{52999} It binds to rat synaptic cortical membranes (Ki = 55 nM) and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit-contanining GABAA receptors in a FLIPR assay (EC50s = 13, 4.5, 5.6, 0.78, and 3.1 µM, respectively).{52999} It inhibits CA1 population spikes in rat hippocampal slices (EC50 = 13 µM) and high potassium/low magnesium-induced seizures in rat pups.{62000,62001} Chronic administration of isoguvacine (2 mg/kg) improves tactile over-reactivity, anxiety-like behaviors, and social impairments in mouse models of autism spectrum disorder (ASD).{62002}
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