Formulation: A solid
Formal Name: (1R,4aR,4bS,7S,10aR)-7-ethenyl-1,2,3,4,4a,4b,5,6,7,8,10,10a-dodecahydro-1,4a,7-trimethyl-1-phenanthrenecarboxylic acid
Purity: ≥95%
Formula Markup: C20H30O2
Formula Weight: 302,5
Shelf life (days): 1460
CAS Number: 5835-26-7
Notes: Isopimaric acid is a diterpenoid resin acid that has been found in P. nigra and has diverse biological activities.{63126,63127,63128,63129} It is active against clinical isolates of epidemic methicillin-resistant S. aureus (EMRSA; MICs = 32-64 µg/ml).{63126} Isopimaric acid is an agonist of retinoid X receptor alpha (RXRα), RXRβ, and RXRγ in a reporter assay using HEK293T cells expressing human receptors (EC50s = 26, 32, and 33 µM, respectively).{63127} It opens large conductance calcium-activated potassium channels (BKCa1.1/KCa1.1) in HEK293 cells expressing recombinant channels and the activating β1 regulatory subunit when used at a concentration of 10 µM.{63128} Isopimaric acid potentiates reductions in field excitatory postsynaptic potential (fEPSP) slopes in hippocampal slices and decreases escape latency in the Morris water maze in a 3xTg mouse model of Alzheimer’s disease.{63129} It has been found as an environmental contaminant in pulp and paper mill effluent.{63130}