Formulation: A solid
Formal Name: 4-(1-hydroxy-2-((propan-2-yl-d7)amino)ethyl)benzene-1,2-diol, monohydrochloride
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C11H10D7NO3 • HCl
Formula Weight: 254,8
Shelf life (days): 1460
CAS Number: 2517584-04-0
Notes: Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol (Item No. 15592) by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively).{25395} It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM).{25571} In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectomized rats.{58617} It reduces blood pressure and increases heart rate in renal hypertensive rabbits.{58618} Isoproterenol inhibits histamine-induced bronchospasms in anesthetized dogs.{58619} Formulations containing isoproterenol have been used in the treatment of bradydysrhythmias and to improve breathing during anesthesia.
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