Formulation: A solid
Formal Name: 1,2,5′,5′a,7′,8′,10′,10′a-octahydro-1′-methyl-2-oxo-spiro[3H-indole-3,6′(4′aH)-[1H]pyrano[3,4-f]indolizine]-4′-carboxylic acid, methyl ester
Purity: ≥98%
Formula Markup: C21H24N2O4
Formula Weight: 368,4
Shelf life (days): 1460
CAS Number: 5171-37-9
Notes: Isopteropodine is an oxindole alkaloid that has been found in U. tomentosa and has diverse biological activities.{51656,51657,51658,51659} It induces activation of the pregnane X receptor (PXR) in a reporter assay using DPX2 cells expressing the human receptor (EC50 = 0.7656 µM).{51656} Isopteropodine is a positive modulator of M1 muscarinic acetylcholine receptors (mAChRs) and the serotonin (5-HT) receptor subtype 5-HT2 (EC50s = 9.92 and 14.5 µM for the rat receptors, respectively).{51657} It is active against S. aureus and B. subtilis (MICs = 408 and 679 µM, respectively).{51658} Isopteropodine (100 µM) inhibits the proliferation of CCRF CEM C7H2 lymphoblastic leukemia cells.{51659}
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