ITH15004, CAS 2600675-12-3

Formulation: A crystalline solid

Formal Name: 2-(6-chloro-9H-purin-9-yl)-1-(2,4-dichlorophenyl)-ethanone

Purity: ≥98%

Formula Markup: C13H7Cl3N4O

Formula Weight: 341,6

Shelf life (days): 730

CAS Number: 2600675-12-3

Notes: ITH15004 is a non-nucleotide antagonist of the purinergic P2X7 receptor (IC50 = 9 µM in HEK293 cells expressing the human receptor).{57491} It inhibits ATP-induced currents in X. laevis oocytes expressing the human P2X7 receptor when used at a concentration of 100 µM. ITH15004 (1 µM) decreases IL-1β release from LPS-primed, ATP-stimulated isolated mouse peritoneal macrophages. It has high permeability in a parallel artificial membrane permeability assay (PAMPA).

• SKU: CAY33667-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33667-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK