JHU37152, CAS 2369979-67-7

Formulation: A solid

Formal Name: 8-chloro-11-(4-ethyl-1-piperazinyl)-1-fluoro-5H-dibenzo[b,e][1,4]diazepine

Purity: ≥98%

Formula Markup: C19H20ClFN4

Formula Weight: 358,8

Shelf life (days): 1460

CAS Number: 2369979-67-7

Notes: JHU37152 is an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors (mAChRs).{67566} It binds to hM3Dq and hM4Di receptors (Kis = 1.8 and 8.7 nM, respectively) and induces Gαo1 activation in HEK293 cells expressing hM3Dq or hM4Di (EC50s = 5 and 0.5 nM, respectively). In vivo, JHU37152 (1 mg/kg) inhibits locomotor activity in D1-hM3Dq and D1-hM4Di transgenic mice.

• SKU: CAY39532-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39532-10
• Package Unit: 10 mg
• Quantity Unit: STK