JHU37160, CAS 2369979-68-8

Formulation: A solid

Formal Name: 8-chloro-11-(4-ethyl-1-piperazinyl)-4-fluoro-5H-dibenzo[b,e][1,4]diazepine

Purity: ≥98%

Formula Markup: C19H20ClFN4

Formula Weight: 358,8

Shelf life (days): 1460

CAS Number: 2369979-68-8

Notes: JHU37160 is an activator of designer receptors exclusively activated by designer drugs (DREADDs) derived from human muscarinic acetylcholine receptors (mAChRs).{67566} It binds to hM3Dq and hM4Di receptors (Kis = 1.9 and 3.6 nM, respectively) and induces Gαo1 activation in HEK293 cells expressing hM3Dq or hM4Di (EC50s = 18.5 and 0.2 nM, respectively). In vivo, JHU37160 (0.01-1 mg/kg) inhibits locomotor activity in D1-hM3Dq and D1-hM4Di transgenic mice.

• SKU: CAY39531-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39531-5
• Package Unit: 5 mg
• Quantity Unit: STK