JNJ-17203212, CAS 821768-06-3

Formulation: A crystalline solid

Formal Name: 4-[3-(trifluoromethyl)-2-pyridinyl]-N-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarboxamide

Purity: ≥98%

Formula Markup: C17H15F6N5O

Formula Weight: 419,3

Shelf life (days): 1460

CAS Number: 821768-06-3

Notes: JNJ-17203212 is a transient receptor potential vanilloid 1 (TRPV1) antagonist (Ki = 72 nM for the recombinant guinea pig channel).{56185} It inhibits guinea pig TRPV1 channel activation induced by capsaicin (Item Nos. 92350 / 10010743) or pH decrease (IC50s = 58 and 470 nM, respectively). JNJ-17203212 (20 mg/kg) reduces the number of citric acid- or capsaicin-induced coughs in guinea pigs. It reduces spontaneous and palpitation-induced flinching and guarding in a mouse model of bone cancer pain when administered at a dose of 30 mg/kg.{14469} JNJ-17203212 decreases capsaicin-induced production of calcitonin gene-related peptide (CGRP) in a dose-dependent manner and inflammatory soup-induced trigeminal expression of cfos in rat models of migraine.{56186}

• SKU: CAY30930-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30930-25
• Green Labware: No
• Package Unit: 25 mg
• Quantity Unit: STK