Formulation: A solid
Formal Name: D-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-lysyl-L-norleucyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-α-glutamyl-L-lysyl-L-glutaminyl-L-α-glutamyl-L-lysyl-L-α-glutamyl-L-lysyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-alanyl-L-asparaginyl-L-asparaginyl-L-arginyl-L-leucyl-L-leucyl-L-leucyl-L-α-aspartyl-L-threonyl-L-isoleucinamide, trifluoroacetate salt
Purity: ≥95%
Formula Markup: C162H276N48O46 • XCF3COOH
Formula Weight: 3632,2
Shelf life (days): 1460
Notes: K 41498 is a peptide antagonist of corticotropin-releasing factor receptor 2α (CRF2α) and CRF2β (Kis = 0.66 and 0.62 nM, respectively, in HEK293 cells expressing the human receptors).{64934} It is selective for CRF2α and CRF2β over CRF1 (Ki = 425 nM in HEK293 cells expressing the human receptor). K 41498 (1.84 µg/animal, i.v.) prevents hypotension induced by urocortin (Item No. 24745) in rats. Intrathecal administration of K 41498 (0.075-0.5 µmol/animal) decreases the mechanical paw withdrawal threshold in a rat model of nociception induced by complete Freund's adjuvant.{64935}
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