Formulation: A crystalline solid
Formal Name: 2-[2,6-diiodo-4-[(2-methyl-3-benzofuranyl)methyl]phenoxy]-acetic acid
Purity: ≥95%
Formula Markup: C18H14I2O4
Formula Weight: 548,1
Shelf life (days): 1460
CAS Number: 147030-48-6
Notes: KB-130015 is an antiarrhythmic agent and a derivative of amiodarone (Item No. 15213).{24578} It inhibits potassium currents induced by acetylcholine or adenosine in isolated guinea pig atrial myocytes (IC50s = 0.82 and 0.57 µM, respectively).{62080} KB-130015 activates or inhibits the voltage-gated potassium channel human-ether-a-go-go (hERG), also known as Kv11.1, in HEK293 cells in a voltage-dependent manner.{62081} It activates large-conductance calcium-activated potassium (KCa1.1/BKCa) channels in HEK293 cells expressing the KCa1.1 subunit Slo1 (EC50 = 20.2 μM).{62082} KB-130015 (40 mg/kg) prolongs the duration of electrically stimulated action potentials in guinea pig papillary muscle ex vivo.{24578} It is also an antagonist of human thyroid hormone receptor α (TRα) and TRβ (IC50s = 2.2 and 4.1 µM, respectively, in reporter assays).
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