Kdo2-Lipid A (sodium salt)

Formulation: A solution in pyrogen-free double distilled water

Formal Name: 1-(dihydrogen phosphate) 3-[(3R)-3-hydroxytetradecanoate] O-3-deoxy-α-D-manno-2-octulopyranosonosyl-(2→4)-O-3-deoxy-α-D-manno-2-octulopyranosonosyl-(2→6)-O-2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphono-β-D-glucopyranosyl-(1→6)-2-deoxy-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-α-D-glucopyranose, tetrasodium salt

Formula Markup: C110H198N2O39P2 • 4Na

Formula Weight: 2326,7

Shelf life (days): 730

Notes: Kdo2-Lipid A is the active component of LPS.{14300} It selectively induces Il-6 expression in wild-type RAW 264.7 macrophages, but not Tlr4-/- RAW 264.7 macrophages, when used at a concentration of 1 µg/ml. Kdo2-Lipid A (100 ng/ml) increases the levels of prostaglandin D2 (PGD2; Item No. 12010), PGE2 (Item No. 14010), and Tnf-α in RAW 264.7 macrophages to a similar extent as LPS. It has been used in lipidomic studies to assess changes in lipid expression and metabolism induced by immune activation in macrophages.{14665,19529}

• SKU: CAY10860-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 10860-1
• Package Unit: 1 mg
• Quantity Unit: STK