Formulation: A solid
Formal Name: 4-(1-(methyl-13C-d3)piperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C18[13C]H16D3NOS
Formula Weight: 313,4
Shelf life (days): 1460
CAS Number: 2748522-40-7
Notes: Ketotifen-13C-d3 is intended for use as an internal standard for the quantification of ketotifen (Item No. 20303) by GC- or LC-MS. Ketotifen is a histamine H1 receptor antagonist (Ki = 1.3 nM) and mast cell stabilizer.{21941,48520} It is selective for H1 receptors over H2 and H3 receptors (Kis = 987 and 2,500 nM, respectively).{21941} Ketotifen (50 and 100 μM) inhibits degranulation of rat peritoneal mast cells induced by compound 48/80 (Item No. 22173).{48520} It inhibits the passive cutaneous anaphylaxis (PCA) reaction in rats by 54.6% when administered orally at a dose of 20 mg/kg.{32040} Ketotifen (30 mg/kg) inhibits the quick phase airway response in a rat ovalbumin-induced immediate airway response model.{26817} Formulations containing ketotifen have been used in the treatment of itching associated with allergic conjunctivitis.
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