Formulation: A solid
Formal Name: (S)-N1-((6S,9R,15S)-9-((1H-indol-3-yl)methyl)-1-amino-6-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-15-benzyl-1-imino-8,11,14,17-tetraoxo-2,7,10,13,16-pentaazaoctadecan-18-yl)-2-((S)-2-((S)-2-((R)-2-acetamidopropanamido)-4-amino-4-oxobutanamido)-3-(1H-indol-3-yl)propanamido)succinamide, 2,2,2-trifluoroacetic acid
Purity: ≥98%
Formula Markup: C63H78N18O13 • XCF3COOH
Formula Weight: 1295,4
Shelf life (days): 1460
CAS Number: 1848962-29-7
Notes: Kisspeptin-234 is a peptide antagonist of the kisspeptin receptor, previously known as G protein-coupled receptor 54 (GPR54).{66352} It inhibits kisspeptin-10-induced inositol phosphate production in CHO cells expressing the human kisspeptin receptor (IC50 = 7 nM) and kisspeptin-10-induced firing of isolated mouse gonadotropin-releasing hormone (GnRH) neurons. In vivo, kisspeptin-234 inhibits pulsatile GnRH secretion in pubertal female rhesus monkeys. It also inhibits kisspeptin-10-induced luteinizing hormone secretion in adult male rats and mice.
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