KM 11060, CAS 774549-97-2

Formulation: A crystalline solid

Formal Name: 7-chloro-4-[4-[(4-chlorophenyl)sulfonyl]-1-piperazinyl]-quinoline

Purity: ≥98%

Formula Markup: C19H17Cl2N3O2S

Formula Weight: 422,3

Shelf life (days): 1460

CAS Number: 774549-97-2

Notes: KM 11060 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation carried by 90% of cystic fibrosis patients.{36264} It increases cell surface expression and restores chloride transport function of F508del-CFTRs in BHK cells at a concentration of 10 μM. KM 11060 restores F508del-CFTR function, as measured by cAMP-stimulated iodide efflux, in CFBE41o- human airway epithelial cells at a concentration of 10 nM. It also restores the secretory response to approximately 51% of wild-type levels ex vivo in ileum isolated from F508del-CFTR mice at a concentration of 20 μM.

• SKU: CAY23481-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 23481-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK