Product Type: Inhibitor
CAS No.: 218924-25-5
MolecularFormula: C13H11NO4
Molecular Weight: 245,2
Source: Synthetic
Purity: >98% (HPLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (30 mg/ml)
Appearance: Off-white powder
PubChem CID: 46195007
Scientific Background: KNK 437 is an inhibitor of the acquisition of thermotolerance caused by the induction of HSPs, including HSP105, HSP70, and HSP40 in human colon carcinoma cells (1). It has also been tested in anti-tumor therapy of colorectal cancer (2).
References: 1. Yokota S., Kitahara M., and Nagata K. (2000) Cancer Res. 60 (11): 2942-2948. 2. Yang S., et al. (2020) Oncogene. 39: 249-261.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.