Formulation: A crystalline solid
Formal Name: 2-amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-1,3-propanediol, monohydrochloride
Purity: ≥98%
Formula Markup: C24H26ClNO3S • HCl
Formula Weight: 480,4
Shelf life (days): 1460
CAS Number: 509088-69-1
Notes: KRP 203 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist.{68471} It selectively induces calcium mobilization in CHO-K1 cells expressing mouse S1P1 over mouse S1P3 and S1P4 (EC50s = 0.84, >1,000, and 9.61 nM, respectively). In vivo, KRP 203 (0.3 mg/kg) prevents the development of wasting syndrome, decreases diarrhea and colonic inflammatory cell infiltration, and increases colon length in an IL10-/- mouse model of colitis. KRP 203 inhibits inflammatory cell infiltration and prolongs allograft survival in a rat model of minor histocompatibility complex-disparate heart transplantation.{16428}
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