Formulation: A solid
Formal Name: 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]-pyridine
Purity: ≥98%
Formula Markup: C24H20BrClN2O
Formula Weight: 467,8
Shelf life (days): 1460
CAS Number: 191034-25-0
Notes: L-168,049 is a glucagon receptor (GCGR) antagonist (IC50s = 3.7 and 179 nM in the absence and presence of MgCl2, respectively).{69829} It prevents glucagon-induced increases in IL-1β and IL-6 levels in, and levels secreted from, HepG2 cells when used at a concentration of 3.7 nM.{69830} L-168,049 inhibits glucagon-induced increases in the mRNA encoding complement 3 (C3), C-reactive protein (CRP), and fibrinogen in HepG2 cells. In vivo, L-168,049 (1 µM in drinking water) inhibits glucagon-induced increases in the hepatic levels of NOD-like receptor protein 3 (NLRP3), phosphorylated NF-κB, and phosphorylated Stat3 in mice.
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