L-732,138, CAS 148451-96-1

Formulation: A crystalline solid

Formal Name: N-acetyl-L-tryptophan [3,5-bis(trifluoromethyl)phenyl]methyl ester

Purity: ≥98%

Formula Markup: C22H18F6N2O3

Formula Weight: 472,4

Shelf life (days): 1460

CAS Number: 148451-96-1

Notes: L-732,138 is a neurokinin-1 (NK1) receptor antagonist (IC50 = 1.6 nM in CHO cells expressing the human receptor).{57090} It is selective for NK1 over NK2 and NK3 receptors (IC50s = >5,000 nM for both). L-732,138 inhibits the growth of COLO 858, MEL HO, and COLO 679 melanoma cells (IC50s = 44.6, 76.3, and 64.2 μM, respectively), as well as induces apoptosis in these cell lines.{57091} It inhibits plasma extravasation induced by substance P (Item No. 24035) in guinea pigs (ID50 = 8 mg/kg, i.p.).{57090} L-732,138 attenuates mechanical allodynia and cold hyperalgesia in a rat model of neuropathic pain induce by chronic constriction injury of the sciatic nerve.{57092}

• SKU: CAY30894-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 30894-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK