Formulation: A solid
Formal Name: 3-(2,5-difluorophenyl)-7-(1,1-dimethylethyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazolo[4,3-b]pyridazine
Purity: ≥95%
Formula Markup: C19H19F2N7O
Formula Weight: 399,4
Shelf life (days): 1460
CAS Number: 286456-42-6
Notes: L-838,417 is a partial agonist of α2-, α3-, and α5 subunit-containing GABAA receptors.{72213} It potentiates GABA-induced currents in LTK- cells expressing α2β3γ2, α3β3γ2, or α5β3γ2 subunit-containing GABAA receptors when used at a concentration of 100 nM. In vivo, L-838,417 (10 mg/kg) increases the mechanical paw withdrawal threshold in a rat model of spinal nerve ligation-induced static allodynia.{72214} It also decreases social avoidance in a novel environment in adult and adolescent rats, indicating anxiolytic-like activity, when administered at doses of 1 and 2 mg/kg, respectively.{72215}
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