Formulation: A solid
Formal Name: 2-hydroxy-5-[1-hydroxy-2-[(1-methyl-3-(phenyl-d5)propyl)amino]ethyl]-benzamide, monohydrochloride
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C19H19D5N2O3 • HCl
Formula Weight: 369,9
Shelf life (days): 1460
CAS Number: 2713514-78-2
Notes: Labetalol-d5 is intended for use as an internal standard for the quantification of labetalol (Item No. 20249) by GC- or LC-MS. Labetalol is an adrenergic receptor (AR) antagonist.{54376} It inhibits agonist-induced contraction of rabbit aortic strips, decreases in contractile force in isolated guinea pig atria, and vasorelaxation in isolated guinea pig tracheal strips (pA2s = 6.99, 7.68, and 7.54, respectively), tissues that endogenously express high levels of α-, β1-, and β2-ARs, respectively. Labetalol (2.5-25 mg/kg) reduces blood pressure in spontaneously hypertensive rats. It reduces blood pressure in DOC-salt rats, two-kidney Goldblatt rats, and one-kidney dogs. Labetalol (5 mg/kg) reduces infarct size in a dog model of myocardial infarction induced by occlusion of the left anterior descending artery. Topical administration of labetalol (0.25-1% v/v) reduces intraocular pressure in rabbits. Formulations containing labetalol have been used in the treatment of hypertension.
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