Formulation: A solid
Formal Name: 6-(5,6-dichlorophenyl-2,3,4-d3)-1,2,4-triazine-3,5-diamine
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C9H4Cl2D3N5
Formula Weight: 259,1
Shelf life (days): 1460
CAS Number: 1132746-94-1
Notes: Lamotrigine-d3 is intended for use as an internal standard for the quantification of lamotrigine (Item No. 15428) by GC- or LC-MS. Lamotrigine is an anticonvulsant.{25270} It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 μM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can be reversed by the N-type calcium channel blocker ω-conotoxin GVIA (Item No. 24114) and P-type calcium channel blocker ω-agatoxin IVA (Item No. 21605).{25270,64617} Lamotrigine protects against seizures induced by maximal electroshock (MES) in mice and rats (ED50s = 10.1 and 7.4 µmol/kg, respectively).{64618} It also decreases mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 47 µmol/kg).{25270} Formulations containing lamotrigine have been used in the treatment of epilepsy and bipolar disorder.
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