Formulation: A crystalline solid
Formal Name: 1-(6-benzothiazolylsulfonyl)-5-chloro-1H-indole-2-butanoic acid
Purity: ≥98%
Formula Markup: C19H15ClN2O4S2
Formula Weight: 434,9
Shelf life (days): 1460
CAS Number: 927961-18-0
Notes: Lanifibranor is an agonist of peroxisome proliferator-activated receptors (PPARs) with EC50 values of 1,537, 866, and 206 nM for human recombinant PPARα, PPARβ, and PPARγ, respectively, for transactivation activity.{42553} It increases β-oxidation in Huh-7 and C2C12 cells when used at concentrations of 1 and 3 µM, respectively, and increases the expression of the PPARγ target genes adipocyte protein 2 (aP2) and adiponectin in adipocytes. Lanifibranor reduces plasma glucose and triglyceride levels in a db/db mouse model of type 2 diabetes when administered at doses of 10 and 30 mg/kg for five days. It also increases plasma adiponectin levels and decreases collagen deposition in a carbon tetrachloride-induced mouse model of non-alcoholic steatohepatitis (NASH).
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