Formulation: A solid
Formal Name: 20-ethyl-1α,14α,16β-trimethoxy-aconitane-4,8,9-triol 4-[2-(acetylamino)benzoate]
Purity: ≥90%
Formula Markup: C32H44N2O8
Formula Weight: 584,7
Shelf life (days): 1460
CAS Number: 32854-75-4
Notes: Lappaconitine is a diterpene alkaloid that has been found in A. sinomontanum and has diverse biological activities.{58715,58716,58717} It is an inhibitor of voltage-gated sodium channel 1.7 (Nav1.7; IC50 = 27.67 µM for the human channel).{58716} Lappaconitine has antiarrhythmic activity in a rat model of aconitine-induced arrhythmia with an ED50 value of 0.05 µg/kg.{58717} It increases the mechanical and thermal paw withdrawal thresholds in rats in a model of spinal nerve ligation-induced neuropathic pain (ED50s = 1.1 and 1.6 mg/kg, respectively).{58715}