Lappaconitine, CAS 32854-75-4

Formulation: A solid

Formal Name: 20-ethyl-1α,14α,16β-trimethoxy-aconitane-4,8,9-triol 4-[2-(acetylamino)benzoate]

Purity: ≥90%

Formula Markup: C32H44N2O8

Formula Weight: 584,7

Shelf life (days): 1460

CAS Number: 32854-75-4

Notes: Lappaconitine is a diterpene alkaloid that has been found in A. sinomontanum and has diverse biological activities.{58715,58716,58717} It is an inhibitor of voltage-gated sodium channel 1.7 (Nav1.7; IC50 = 27.67 µM for the human channel).{58716} Lappaconitine has antiarrhythmic activity in a rat model of aconitine-induced arrhythmia with an ED50 value of 0.05 µg/kg.{58717} It increases the mechanical and thermal paw withdrawal thresholds in rats in a model of spinal nerve ligation-induced neuropathic pain (ED50s = 1.1 and 1.6 mg/kg, respectively).{58715}

• SKU: CAY28747-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 28747-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK