Latanoprostene Bunod, CAS 860005-21-6

Formulation: A solution in ethanol

Formal Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic acid, 4-(nitrooxy)butyl ester

Purity: ≥95%

Formula Markup: C27H41NO8

Formula Weight: 507,6

Shelf life (days): 365

CAS Number: 860005-21-6

Notes: Latanoprostene bunod is a nitric oxide-donating prostaglandin F2α (FP) receptor agonist that is converted to latanoprost (free acid) (Item No. 16811) and nitric oxide (NO) in vivo.{43936} It induces cGMP accumulation in PC12 and HEK293 cells (EC50s = 1.6 and 9.2 μM, respectively). Topical administration of latanoprostene bunod (0.036% solution) reduces intraocular pressure (IOP) in canine and rabbit models of glaucoma. It also decreases IOP in a cynomolgus monkey model of laser-induced ocular hypertension.

• SKU: CAY25830-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 25830-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK