Formulation: A solid
Formal Name: 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester, monohydrochloride
Purity: ≥98%
Formula Markup: C36H41N3O6 • HCl
Formula Weight: 648,2
Shelf life (days): 1460
CAS Number: 132866-11-6
Notes: Lercanidipine is a dihydropyridine L-type calcium channel blocker.{46593} It binds to rat brain and heart homogenates (Kis = 0.24-0.3 and 0.22 nM, respectively, in radioligand binding assays) and inhibits potassium-induced contraction of isolated rat aorta (IC50 = 1.3 nM). Lercanidipine reduces diastolic blood pressure (DBP) in normotensive and spontaneously hypertensive rats with ED25 values of 16.3 and 15.5 µg/kg, respectively. Formulations containing lercanidipine have been used in the treatment of hypertension.
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