Levobetaxolol (hydrochloride), CAS 116209-55-3

Formulation: A crystalline solid

Formal Name: (2S)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol, monohydrochloride

Purity: ≥98%

Formula Markup: C18H29NO3 • HCl

Formula Weight: 343,9

Shelf life (days): 1460

CAS Number: 116209-55-3

Notes: Levobetaxolol is an isomer of betaxolol (Item No. 18625) and antagonist of the β1-adrenergic receptor (β1-AR; Ki = 0.76 nM for the human receptor).{58318} It is selective for β1-ARs over β2-ARs (Ki = 32.6 nM), as well as a panel of 89 additional receptors (IC50s = >1 µM). Levobetaxolol inhibits cAMP production induced by isoproterenol (Item No. 15592) in human non-pigmented ciliary epithelial cells (Ki = 16.4 nM). Topical application of levobetaxolol (150 µg/eye) reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension. Formulations containing levobetaxolol have been used in the treatment of glaucoma.

• SKU: CAY33435-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 33435-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK