Formulation: A crystalline solid
Formal Name: 1-butyl-N-(2,6-dimethylphenyl)-(2S)-2-piperidinecarboxamide, monohydrochloride
Purity: ≥98%
Formula Markup: C18H28N2O • HCl
Formula Weight: 324,9
Shelf life (days): 1460
CAS Number: 27262-48-2
Notes: Levobupivacaine is a sodium channel blocker and local anesthetic, as well as the levorotary stereoisomer of bupivacaine (Item No. 16618).{58122,58123,42580} It inhibits cardiac sodium channel currents (INa) by 57.8% in isolated guinea pig ventricular myocytes when used at a concentration of 10 μM.{58122} Levobupivacaine (10 μM) reduces the maximal rate of depolarization (Vmax) and action potential duration to 76.7 and 83.4% of controls, respectively, in isolated guinea pig papillary muscle.{58123} It induces a complete block of proprioception, motor function, and nociception in the hindleg of rats when administered at a dose of 7.7 mM by percutaneous injection into the sciatic nerve.{42580}
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