Formulation: A crystalline solid
Formal Name: 2-[di(ethyl-d5)amino]-N-(2,6-dimethylphenyl)-acetamide
Purity: ≥99% deuterated forms (d1-d10)
Formula Markup: C14H12D10N2O
Formula Weight: 244,4
Shelf life (days): 1460
CAS Number: 851528-09-1
Notes: Lidocaine-d10 is intended for use as an internal standard for the quantification of lidocaine by GC- or LC-MS. Lidocaine is an inhibitor of voltage-gated sodium channels (Navs) and a local anesthetic.{58904,58905,58906} It inhibits Nav1.2 (Ki = 11 µM), adult and neonatal Nav1.5 (IC50s = 380.1 and 360 µM, respectively), and Nav1.7 and Nav1.8 channels (IC50s = 450 and 104 µM, respectively) expressed in Xenopus oocytes. Topical administration of lidocaine (1-2%) reduces escape behavior in a rhesus monkey model of noxious electrical cutaneous pain.{58907} Formulations containing lidocaine have been used as local and regional anesthetics.
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