Formulation: A solid
Formal Name: 4-[[[(8-chloro-1,4-dihydro-1-methyl[1]benzopyrano[4,3-c]pyrazol-3-yl)carbonyl](phenylmethyl)amino]methyl]-benzoic acid
Purity: ≥98%
Formula Markup: C27H22ClN3O4
Formula Weight: 487,9
Shelf life (days): 1460
CAS Number: 1773489-72-7
Notes: LMB763 is a partial agonist of the farnesoid X receptor (FXR; EC50 = 7 nM).{50981} It is selective for FXR over a panel of enzymes, ion channels, nuclear receptors, and G protein-coupled receptors, including the androgen receptor, estrogen receptor α (ERα), and G protein-coupled bile acid receptor 1 (GPBAR1; EC50s = >30, >30, and >80 µM, respectively). LMB763 induces expression of the FXR target genes encoding the bile salt export pump and short heterodimer partner in isolated rat hepatocytes in a concentration-dependent manner. It decreases non-alcoholic fatty liver disease (NAFLD) scores and liver fibrosis in a rat model of non-alcoholic steatohepatitis (NASH).
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